| Annotated protein: | Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I). Gene symbol: EIF4EBP1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q62622 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ EIF4EBP1 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic cytosol (GO:0099524) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Tang SJ, et al. "A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus" Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):467-72 PMID:11756682 |
| Figure(s): | fig 3 |
| Annotation description: | The figure shows the synaptic co-localization of 4E-BP1 with synapse in hippocampal neurons (P2; 14 DIV), furthermore 4E-EBP1 colocalize with PSD-95, postsynaptic marker. 24/9/2017 Pim - Literal: "The mTOR-positive regions were observed in the dendritic shaft in a diffuse pattern that extended into synaptic regions (Fig. (Fig.33Al). Consistent with the notion of postsynaptic localization of these proteins, double labeling with PSD-95 showed the signals from eIF-4E, 4E-BP1, and mTOR at synaptic regions almost completely overlapped with PSD-95 signals." |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Alexandros Kanellopoulos (ORCID:0000-0002-2094-7491) Vittoria Mariano (ORCID:0000-0002-9848-0262) Achsel Tilmann (ORCID:0000-0002-1190-4481) Claudia Bagni (ORCID:0000-0002-4419-210X) |
| Lab: | Department of Fundamental Neurosciences, University of Lausanne, CH-1006 Lausanne, Switzerland; Dept Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy |
| Additional literature: | eIF4E-BP1 is detected in the growth cones of retinal explants by immunofluorescence microscopy (Fig 3B), i.e., the protein can also be axonal. @ PMID:25886013 eIF4E-BP1 is deteced in sciatic nerve preparations by immunofluorescence microscopy (Fig 9), i.e., the protein can also be axonal. @ PMID:26180210 |
| SynGO annotation ID: | 1368 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |