| Annotated protein: | Eukaryotic translation initiation factor 4B. Gene symbol: EIF4B. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q5RKG9 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ EIF4B |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Eom T, et al. "Neuronal BC RNAs cooperate with eIF4B to mediate activity-dependent translational control" J Cell Biol. 2014 Oct 27;207(2):237-52 PMID:25332164 |
| Figure(s): | fig 7 |
| Annotation description: | eIF4B is found dendritically (near but doesn't co-localize completely with synaptophysin) in hippocampal primary neurons by immunofluorescence. 24/9/2017 Pim - Authors refer to the localization as 'synapto-dendritic". - A role for eIF4B phosphorylation in LTP induction is concluded, but to my opinion this is purely correlational and therefore would refrain from annotating this. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Alexandros Kanellopoulos (ORCID:0000-0002-2094-7491) Vittoria Mariano (ORCID:0000-0002-9848-0262) Achsel Tilmann (ORCID:0000-0002-1190-4481) Claudia Bagni (ORCID:0000-0002-4419-210X) |
| Lab: | Department of Fundamental Neurosciences, University of Lausanne, CH-1006 Lausanne, Switzerland; Dept Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy |
| SynGO annotation ID: | 1367 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |