| Annotated protein: | Eukaryotic initiation factor 4A-III (eIF-4A-III) (eIF4A-III) (EC 3.6.4.13) (ATP-dependent RNA helicase DDX48) (ATP-dependent RNA helicase eIF4A-3) (DEAD box protein 48) (Eukaryotic translation initiation factor 4A isoform 3) [Cleaved into: Eukaryotic initiation factor 4A-III, N-terminally processed]. Gene symbol: EIF4A3. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q3B8Q2 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ EIF4A3 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of translation at postsynapse, modulating synaptic transmission (GO:0099578) |
| Synapse type(s): | cerebral cortex, glutamatergic |
| Annotated paper: | Giorgi C, et al. "The EJC factor eIF4AIII modulates synaptic strength and neuronal protein expression" Cell. 2007 Jul 13;130(1):179-91 PMID:17632064 |
| Figure(s): | Fig.1, fig.4/5 |
| Annotation description: | Fig 5 shows that eIF4AIII Knockdown Increases Excitatory Synaptic Transmission and GLUR1 Levels at Synapses in cultured cortical neurons (DIV7). Furthermore in fig. 2 and 3 show that eIF4AIII binds mRNAs that are typically dendritic, such as Arc 13/11/2017 Pim - The eIF4AIII protein is shown 1) to be localized to dendrites and 2) to regulate the expression of the postsynaptic Arc and Glur1 proteins. This allows for the straight forward inference to 'postsynapse'. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | RNAi / shRNA Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal Electrophysiology (generic) |
| Annotator(s): | Alexandros Kanellopoulos (ORCID:0000-0002-2094-7491) Vittoria Mariano (ORCID:0000-0002-9848-0262) Achsel Tilmann (ORCID:0000-0002-1190-4481) Claudia Bagni (ORCID:0000-0002-4419-210X) |
| Lab: | Department of Fundamental Neurosciences, University of Lausanne, CH-1006 Lausanne, Switzerland; Dept Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy |
| SynGO annotation ID: | 1366 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |