| Annotated protein: | PH and SEC7 domain-containing protein 2 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 C) (Exchange factor for ARF6 C) (Pleckstrin homology and SEC7 domain-containing protein 2). Gene symbol: PSD2. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q6P1I6 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PSD2 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | cerebellum, glutamatergic |
| Annotated paper: | Matsuya S, et al. "Cellular and subcellular localization of EFA6C, a third member of the EFA6 family, in adult mouse Purkinje cells" J Neurochem. 2005 May;93(3):674-85 PMID:15836626 |
| Figure(s): | Fig8B and Fig9 |
| Annotation description: | Fig9AB shows EFA6C localization in dendrites of Purkinje cells and spines by light microscopy, Fig9D shows postsynaptic localization by immuno-EM, which is verified by subcellular fractionation where EFA6C shows enrichment in the PSD95 fraction (Fig8B). 24/10/2017 Pim - The authors mention "showing strong immunoreactivity in the dendritic spines (sp) having the post-synaptic density (arrows)". The immuno-EM picture is rather vague but staining seems to be more widespread than the PSD itself. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy Confocal Western blot Biochemical fractionation (generic) |
| Annotator(s): | Jan van Weering (ORCID:0000-0001-5259-4945) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 1359 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |