Annotated protein:	Glutamate receptor ionotropic, NMDA 2B (GluN2B) (Glutamate [NMDA] receptor subunit epsilon-2) (N-methyl D-aspartate receptor subtype 2B) (NMDAR2B) (NR2B) (N-methyl-D-aspartate receptor subunit 3) (NR3) (hNR3). Gene symbol: GRIN2B. Taxonomy: Homo sapiens (Human). Uniprot ID: Q13224
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SynGO gene info:	SynGO data @ GRIN2B
Ontology domain:	Biological Process
SynGO term:	ligand-gated ion channel activity involved in regulation of presynaptic membrane potential (GO:0099507)
Annotated paper:	Bidoret C, et al. "Presynaptic NR2A-containing NMDA receptors implement a high-pass filter synaptic plasticity rule" Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):14126-31 PMID:19666514
Figure(s):	Fig. 4
Annotation description:	Electrophysiological characterisation of NR2B overexposed in HEK cells using WC patch-clamp. rule: NAS_MFCC-BP rationale: Protein has ligand-gated ion channel receptor activity and is localized in the presynaptic membrane (shown with high-resolution technique). The inference to term 'ligand-gated ion channel activity involved in regulation of presynaptic membrane potential (GO:0099507)' is trivial and non-controversial. Pinf_CC: [Q00960] SyNGO ID 1350 (PMID:19666514, EM) [Q00960] SyNGO ID 1386 (PMID:23159309, EM)
Evidence tracking, Biological System:	Non-neuronal tissue
Evidence tracking, Protein Targeting:	Over-expression
Evidence tracking, Experiment Assay:	Whole-cell patch clamp
Non-tracable Author Statement (NAS):	This annotation required some inference over additional information/literature, and is not solely based on observations made in the annotated paper by its original authors.
Annotator(s):	Niels Cornelisse (ORCID:0000-0001-9425-2935) Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:	Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:	1351
Dataset release (version):	20231201
View annotation as GO-CAM model: