| Annotated protein: | Glutamate receptor ionotropic, NMDA 2B (GluN2B) (Glutamate [NMDA] receptor subunit epsilon-2) (N-methyl D-aspartate receptor subtype 2B) (NMDAR2B) (NR2B). Gene symbol: GRIN2B. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q00960 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GRIN2B |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of presynaptic membrane (GO:0099056) |
| Synapse type(s): | Parallel fibre (cerebellum -> Purkinje-cell) |
| Annotated paper: | Bidoret C, et al. "Presynaptic NR2A-containing NMDA receptors implement a high-pass filter synaptic plasticity rule" Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):14126-31 PMID:19666514 |
| Figure(s): | Fig. 3E |
| Annotation description: | localisation of NR2B in presynapse using immuno EM. 22/11/2017 Pim - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Niels Cornelisse (ORCID:0000-0001-9425-2935) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 1350 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |