| Annotated protein: | Transcriptional activator protein Pur-alpha (Purine-rich single-stranded DNA-binding protein alpha). Gene symbol: PURA. Taxonomy: Mus musculus (Mouse). Uniprot ID: P42669 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PURA |
| Ontology domain: | Biological Process |
| SynGO term: | dendritic transport of messenger ribonucleoprotein complex (GO:0098963) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Kanai Y, et al. "Kinesin transports RNA: isolation and characterization of an RNA-transporting granule" Neuron. 2004 Aug 19;43(4):513-25 PMID:15312650 |
| Figure(s): | Fig.1, Fig. 4, Fig.8 |
| Annotation description: | Pur-alpha binds to the motor protein KIF5A, which makes it a possible adapter protein in axo-dendritic transport. 2/10/2017 Pim - shRNA KD of Pur alpha (Fig.8) negatively affects Kinesin5-dependent dendritic transport of mRNA granules that contain transcripts for synapse marker proteins such as CAMKII (Fig.1/5/8) and Arc (Fig.1). |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | RNAi / shRNA Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal IP + WB/MSMS |
| Annotator(s): | Alexandros Kanellopoulos (ORCID:0000-0002-2094-7491) Vittoria Mariano (ORCID:0000-0002-9848-0262) Achsel Tilmann (ORCID:0000-0002-1190-4481) Claudia Bagni (ORCID:0000-0002-4419-210X) |
| Lab: | Department of Fundamental Neurosciences, University of Lausanne, CH-1006 Lausanne, Switzerland; Dept Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy |
| Additional literature: | Puralpha is required for Map2 Localization to Dendrites in the Developing Mouse Hippocampus (Fig. 2), which might indicate problems in the dendritic transport. @ PMID:16511857 |
| SynGO annotation ID: | 1344 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |