Annotated protein:	Transcriptional activator protein Pur-alpha (Purine-rich single-stranded DNA-binding protein alpha). Gene symbol: PURA. Taxonomy: Mus musculus (Mouse). Uniprot ID: P42669
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SynGO gene info:	SynGO data @ PURA
Ontology domain:	Cellular Component
SynGO term:	postsynapse (GO:0098794)
Synapse type(s):	hippocampus, glutamatergic
Annotated paper:	Mitsumori K, et al. "Components of RNA granules affect their localization and dynamics in neuronal dendrites" Mol Biol Cell. 2017 Jun 1;28(11):1412-1417 PMID:28404748
Figure(s):	fig 1a, 1b
Annotation description:	Puralpha and PSD-95 co-localised in mature hippocampal neurons DIV15. 24/9/2017 Pim - Literal: "Puralpha immunoreactivity exhibited a granular staining pattern along dendrites (Figure 1A). About one-third of Puralpha granules were colocalized with PSD-95 (Figure 1, A and E). This suggests that some of the Puralpha-positive RNA granules are localized in postsynaptic spines, given that they are specifically localized to dendrites but not axons"
Evidence tracking, Biological System:	Cultured neurons
Evidence tracking, Protein Targeting:	Antibody (detection)
Evidence tracking, Experiment Assay:	Confocal
Annotator(s):	Alexandros Kanellopoulos (ORCID:0000-0002-2094-7491) Vittoria Mariano (ORCID:0000-0002-9848-0262) Achsel Tilmann (ORCID:0000-0002-1190-4481) Claudia Bagni (ORCID:0000-0002-4419-210X)
Lab:	Department of Fundamental Neurosciences, University of Lausanne, CH-1006 Lausanne, Switzerland; Dept Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy
Additional literature:	Fig.4 shows localization of Puralpha-Containing Granules in dendrites of hippocampal neurons from mouse embryos. @ PMID:15312650 Fig. 8 b shows colocalization of Puralpha and KIF1Bβ in dendrites in mouse cultured cortical neurons (12-14DIV). @ PMID:22945799
SynGO annotation ID:	1343
Dataset release (version):	20231201
View annotation as GO-CAM model: