| Annotated protein: | Gamma-aminobutyric acid type B receptor subunit 1 (GABA-B receptor 1) (GABA-B-R1) (GABA-BR1) (GABABR1) (Gb1). Gene symbol: GABBR1. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q9WV18 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GABBR1 |
| Ontology domain: | Biological Process |
| SynGO term: | G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential (GO:0150047) |
| Annotated paper: | Ng GY, et al. "Identification of a GABAB receptor subunit, gb2, required for functional GABAB receptor activity" J Biol Chem. 1999 Mar 19;274(12):7607-10 PMID:10075644 |
| Figure(s): | Fig. 4B |
| Annotation description: | Patch clamp recordings of potassium currents evoked by activation of G-protein couples GABAB R's containing subunit 1 expressed in Xenopus Oocytes. rule: NAS_MFCC-BP rationale: Protein has G-protein neurotransmitter receptor activity and is localized in the presynaptic membrane (shown with high-resolution technique). The inference to term 'G-protein coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential (GO:0150047)' is trivial and non-controversial. Pinf_CC: [Q9Z0U4] SyNGO ID 1251 (PMID:17924569, EM) |
| Evidence tracking, Biological System: | Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Non-tracable Author Statement (NAS): | This annotation required some inference over additional information/literature, and is not solely based on observations made in the annotated paper by its original authors. |
| Annotator(s): | Niels Cornelisse (ORCID:0000-0001-9425-2935) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 1339 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |