| Annotated protein: | Gamma-aminobutyric acid receptor subunit alpha-5 (GABA(A) receptor subunit alpha-5). Gene symbol: GABRA5. Taxonomy: Homo sapiens (Human). Uniprot ID: P31644 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GABRA5 |
| Ontology domain: | Biological Process |
| SynGO term: | ligand-gated ion channel activity involved in regulation of presynaptic membrane potential (GO:0099507) |
| Annotated paper: | Wang F, et al. "6,2'-Dihydroxyflavone, a subtype-selective partial inverse agonist of GABAA receptor benzodiazepine site" Neuropharmacology. 2007 Sep;53(4):574-82 PMID:17681556 |
| Figure(s): | Fig. 7D |
| Annotation description: | Electrophysiological characterisation of GABAA alpha 5 subunit overexposed in HEK cells with WC patch clamp. rule: NAS_MFCC-BP rationale: Protein has ligand-gated ion channel receptor activity and is localized in the presynaptic membrane (shown with high-resolution technique). The inference to term ligand-gated ion channel activity involved in regulation of presynaptic membrane potential (GO:0099507) is trivial and non-controversial. Pinf_CC: [P19969] SyNGO ID 1263 (PMID:16998906, EM) |
| Evidence tracking, Biological System: | Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Non-tracable Author Statement (NAS): | This annotation required some inference over additional information/literature, and is not solely based on observations made in the annotated paper by its original authors. |
| Annotator(s): | Niels Cornelisse (ORCID:0000-0001-9425-2935) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 1331 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |