| Annotated protein: | Gamma-aminobutyric acid receptor subunit alpha-2 (GABA(A) receptor subunit alpha-2). Gene symbol: GABRA2. Taxonomy: Homo sapiens (Human). Uniprot ID: P47869 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GABRA2 |
| Ontology domain: | Biological Process |
| SynGO term: | ligand-gated ion channel activity involved in regulation of presynaptic membrane potential (GO:0099507) |
| Annotated paper: | Wu X, et al. "gamma-Aminobutyric acid type A (GABAA) receptor alpha subunits play a direct role in synaptic versus extrasynaptic targeting" J Biol Chem. 2012 Aug 10;287(33):27417-30 PMID:22711532 |
| Figure(s): | Fig. 1B,C, Fig. 3B,C, Fig. 6 |
| Annotation description: | Electrophysiological characterisation of GABAA alpha 2 subunit overexpressed in HEK cells, with WC patch-clamp. rule: NAS_MFCC-BP rationale: Protein has ligand-gated ion channel receptor activity and is localized in the presynaptic membrane (shown with high-resolution technique). The inference to term ligand-gated ion channel activity involved in regulation of presynaptic membrane potential (GO:0099507) is trivial and non-controversial. Pinf_CC: [P23576] SyNGO ID 1266 (PMID:11168550, EM) |
| Evidence tracking, Biological System: | Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Non-tracable Author Statement (NAS): | This annotation required some inference over additional information/literature, and is not solely based on observations made in the annotated paper by its original authors. |
| Annotator(s): | Niels Cornelisse (ORCID:0000-0001-9425-2935) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 1326 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |