| Annotated protein: | Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2). Gene symbol: JAK2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q62689 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ JAK2 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynapse to nucleus signaling pathway (GO:1905539) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Nicolas CS, et al. "The Jak/STAT pathway is involved in synaptic plasticity" Neuron. 2012 Jan 26;73(2):374-90 PMID:22284190 |
| Figure(s): | Fig 6c |
| Annotation description: | Authors show that STAT3 and phospho STAT3 translocates from the cytoplasm to the nucleus upon treatment with NMDA, accumulating in the nucleus over time. Pharmacological blockade of JAK2 by using AG490 completely prevents the NMDA-induced accumulation of STAT3 and pSTAT3 in the nucleus, suggesting a key role in the regulation of this process. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Maria Andres-Alonso (ORCID:0000-0002-1585-539X) Michael Kreutz (ORCID:0000-0003-0575-6950) |
| Lab: | RG Neuroplasticity, Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany and Leibniz Group 'Dendritic Organelles and Synaptic Function', Center for Molecular Neurobiology, ZMNH, University MC, Hamburg-Eppendorf, Hamburg, 20251, Germany |
| SynGO annotation ID: | 1320 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |