| Annotated protein: | Caprin-1 (Cytoplasmic activation- and proliferation-associated protein 1) (GPI-anchored protein p137) (GPI-p137) (p137GPI) (RNA granule protein 105). Gene symbol: CAPRIN1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q5M9G3 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CAPRIN1 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Shiina N, et al. "A novel RNA-binding protein in neuronal RNA granules: regulatory machinery for local translation" J Neurosci. 2005 Apr 27;25(17):4420-34 PMID:15858068 |
| Figure(s): | Figure 3A |
| Annotation description: | Figure 3A: Rat hippocampal slices (top and middle) or cultured hippocampal neurons (bottom) were immunostained with anti-RNG105 antibody (green) and costained with anti-RPS6, anti-PSD-95, or anti-staufen antibodies. 25/9/2017 Pim - Literal: "Quantitative analysis revealed that ~88% of the RNG105-localizing granules were associated with ribosomes. Second, some RNG105-localizing granules (~9%) were accumulated near the postsynaptic sites stained with anti-PSD-95 antibody (Fig. 3A), which may be consistent with the previous report that some proportion of polyribosomes is localized near postsynapses" |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Alexandros Kanellopoulos (ORCID:0000-0002-2094-7491) Vittoria Mariano (ORCID:0000-0002-9848-0262) Achsel Tilmann (ORCID:0000-0002-1190-4481) Claudia Bagni (ORCID:0000-0002-4419-210X) |
| Lab: | Department of Fundamental Neurosciences, University of Lausanne, CH-1006 Lausanne, Switzerland; Dept Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy |
| SynGO annotation ID: | 1317 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |