| Annotated protein: | Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2). Gene symbol: JAK2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q62689 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ JAK2 |
| Ontology domain: | Biological Process |
| SynGO term: | modulation of chemical synaptic transmission (GO:0050804) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Nicolas CS, et al. "The Jak/STAT pathway is involved in synaptic plasticity" Neuron. 2012 Jan 26;73(2):374-90 PMID:22284190 |
| Figure(s): | Fig 3f-h |
| Annotation description: | Authors generate two independent shRNAs against the rat sequence of JAK2 in order to investigate the role of the protein in NMDA-LTD. Transfected hippocampal organotypic slices were used to test this. While basal synaptic transmission was unaffected in transfected slices, NMDA-LTD was absent in those neurons expressing the shRNAs against JAK2 while neurons expressing the control shRNA did express LTD as expected. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | RNAi / shRNA |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Annotator(s): | Maria Andres-Alonso (ORCID:0000-0002-1585-539X) Michael Kreutz (ORCID:0000-0003-0575-6950) |
| Lab: | RG Neuroplasticity, Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany and Leibniz Group 'Dendritic Organelles and Synaptic Function', Center for Molecular Neurobiology, ZMNH, University MC, Hamburg-Eppendorf, Hamburg, 20251, Germany |
| SynGO annotation ID: | 1316 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |