| Annotated protein: | Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2). Gene symbol: JAK2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q62689 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ JAK2 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | brain, glutamatergic |
| Annotated paper: | Nicolas CS, et al. "The Jak/STAT pathway is involved in synaptic plasticity" Neuron. 2012 Jan 26;73(2):374-90 PMID:22284190 |
| Figure(s): | Fig 4a, b |
| Annotation description: | Authors perform immunocytochemistry in primary hippocampal cultures and observed JAK immunoreactivity using confocal microscopy. This was found forming clusters decorating dendrites and in colocalization with dendritic spine protrusions labeled with an anti-MAP2 antibody and a subpopulation of clusters labeled with PSD-95. Biochemical subcellular fractionation revealed enrichment of JAK2 in the synaptosomal fraction. |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal Western blot Biochemical fractionation (generic) |
| Annotator(s): | Maria Andres-Alonso (ORCID:0000-0002-1585-539X) Michael Kreutz (ORCID:0000-0003-0575-6950) |
| Lab: | RG Neuroplasticity, Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany and Leibniz Group 'Dendritic Organelles and Synaptic Function', Center for Molecular Neurobiology, ZMNH, University MC, Hamburg-Eppendorf, Hamburg, 20251, Germany |
| SynGO annotation ID: | 1315 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |