| Annotated protein: | Homer protein homolog 3 (Homer-3). Gene symbol: HOMER3. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q99JP6 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ HOMER3 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynaptic neurotransmitter receptor activity (GO:0098962) |
| Annotated paper: | Ango F, et al. "Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein Homer" Nature. 2001 Jun 21;411(6840):962-5 PMID:11418862 |
| Figure(s): | figs 1-3 |
| Annotation description: | Knockdown of Homer3 activates mGluR1 signaling in cerebellar neurons suggesting that Homer3 is a negative regulator of mGluR signaling. 43/11/2017 Pim - The authors show that interaction of Homer3 with the receptor modulates the intrinsic activity of the mGluRs: "Our data show that neuronal activity-dependent modulation of the interaction between a GPCR and its associated intracellular protein can elicit receptor activity independently of agonist binding, and with a time constant different from that of agonist-mediated activation." |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | RNAi / shRNA |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Annotator(s): | Harold MacGillavry (ORCID:0000-0002-6153-3586) Casper Hoogenraad (ORCID:0000-0002-2666-0758) |
| Lab: | Department of Biology, Faculty of Science, Utrecht University, 3584 CH Utrecht, The Netherlands |
| SynGO annotation ID: | 1304 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |