| Annotated protein: | Ankyrin repeat and sterile alpha motif domain-containing protein 1B (Amyloid-beta protein intracellular domain-associated protein 1) (AIDA-1) (E2A-PBX1-associated protein) (EB-1). Gene symbol: ANKS1B. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8BIZ1 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ANKS1B |
| Ontology domain: | Biological Process |
| SynGO term: | postsynaptic process involved in chemical synaptic transmission (GO:0099565) |
| Synapse type(s): | Schaffer collateral synapse (CA3->CA1) |
| Annotated paper: | Tindi JO, et al. "ANKS1B Gene Product AIDA-1 Controls Hippocampal Synaptic Transmission by Regulating GluN2B Subunit Localization" J Neurosci. 2015 Jun 17;35(24):8986-96 PMID:26085624 |
| Figure(s): | Fig. 4, Fig. 6 |
| Annotation description: | Impaired NMDAR-dependent plasticity at Sch-CA1 synapses in AIDA-1 cKO mice (Fig. 6). Altered GluN2A-mediated and GluN2B-mediated synaptic transmission and synaptic expression in AIDA-1 cKO mice (Fig. 4). 6/9/2017 Pim - Since the AIDA-1 protein is preferentially localized in the PSD, the regulation of synaptic transmission and LTP induction is annotated by SynGO. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Field recordings Western blot |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| SynGO annotation ID: | 1296 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |