| Annotated protein: | NMDA receptor synaptonuclear signaling and neuronal migration factor (Juxtasynaptic attractor of caldendrin on dendritic boutons protein) (Jacob protein) (Nasal embryonic luteinizing hormone-releasing hormone factor) (Nasal embryonic LHRH factor). Gene symbol: NSMF. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q9EPI6 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ NSMF |
| Ontology domain: | Biological Process |
| SynGO term: | postsynapse to nucleus signaling pathway (GO:0099527) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Karpova A, et al. "Encoding and transducing the synaptic or extrasynaptic origin of NMDA receptor signals to the nucleus" Cell. 2013 Feb 28;152(5):1119-33 PMID:23452857 |
| Figure(s): | Fig. 3 |
| Annotation description: | Synaptic stimulation via NMDA receptors drives Jacob from synapses and distal dendrites into the nucleus in an ERK-dependent manner. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal Wide-field fluorescence Photoconversion assay |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| SynGO annotation ID: | 1294 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |