Annotated protein: | NMDA receptor synaptonuclear signaling and neuronal migration factor (Juxtasynaptic attractor of caldendrin on dendritic boutons protein) (Jacob protein) (Nasal embryonic luteinizing hormone-releasing hormone factor) (Nasal embryonic LHRH factor). Gene symbol: NSMF. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q9EPI6 |
antibody wiki: | |
SynGO gene info: | SynGO data @ NSMF |
Ontology domain: | Cellular Component |
SynGO term: | postsynapse (GO:0098794) |
Synapse type(s): | neocortex, glutamatergic |
Annotated paper: | Dieterich DC, et al. "Caldendrin-Jacob: a protein liaison that couples NMDA receptor signalling to the nucleus" PLoS Biol. 2008 Feb;6(2):e34 PMID:18303947 |
Figure(s): | Fig. 2F,H |
Annotation description: | Jacob was found as an interaction partner of the postsynaptic calcium sensor caldendrin. By immuno-EM localization it was found in postsynaptic spines (in addition to dendrites). |
Evidence tracking, Biological System: | Intact tissue |
Evidence tracking, Protein Targeting: | Antibody (detection) |
Evidence tracking, Experiment Assay: | Electron Microscopy |
Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
SynGO annotation ID: | 1293 |
Dataset release (version): | 20231201 |
View annotation as GO-CAM model: |