Annotated protein:NMDA receptor synaptonuclear signaling and neuronal migration factor (Juxtasynaptic attractor of caldendrin on dendritic boutons protein) (Jacob protein) (Nasal embryonic luteinizing hormone-releasing hormone factor) (Nasal embryonic LHRH factor). Gene symbol: NSMF. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q9EPI6
antibody wiki:
SynGO gene info:SynGO data @ NSMF
Ontology domain:Cellular Component
SynGO term:postsynapse (GO:0098794)
Synapse type(s):neocortex, glutamatergic
Annotated paper:Dieterich DC, et al. "Caldendrin-Jacob: a protein liaison that couples NMDA receptor signalling to the nucleus" PLoS Biol. 2008 Feb;6(2):e34 PMID:18303947
Figure(s):Fig. 2F,H
Annotation description:Jacob was found as an interaction partner of the postsynaptic calcium sensor caldendrin. By immuno-EM localization it was found in postsynaptic spines (in addition to dendrites).
Evidence tracking, Biological System:Intact tissue
Evidence tracking, Protein Targeting:Antibody (detection)
Evidence tracking, Experiment Assay:Electron Microscopy
Annotator(s):Daniela Dieterich (ORCID:0000-0002-9880-1214)
Rainer Pielot (ORCID:0000-0002-9681-3318)
Karl-Heinz Smalla (ORCID:0000-0002-0269-0311)
Eckart Gundelfinger (ORCID:0000-0001-9377-7414)
Lab:Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany
SynGO annotation ID:1293
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology