| Annotated protein: | Gamma-aminobutyric acid receptor subunit beta-2 (GABA(A) receptor subunit beta-2). Gene symbol: GABRB2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P63138 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GABRB2 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of presynaptic active zone membrane (GO:0099059) |
| Synapse type(s): | globus pallidus, GABAergic |
| Annotated paper: | Chen L, et al. "Subcellular localization of GABAB receptor subunits in rat globus pallidus" J Comp Neurol. 2004 Jun 28;474(3):340-52 PMID:15174078 |
| Figure(s): | Fig.5A-E, Fig.4, Fig. 6C,D, Fig. 8C,D |
| Annotation description: | GABA B2 subunit detection in Globus pallidus synapses. 11/9/2017 Pim - Literal: " At asymmetric synapses, the majority (85%) of the synapse-associated immunogold particles were located at the edges of the synapse (Fig. 5B), accounting for 34% and 51% for pre- and postsynaptic sites, respectively (Fig. 4B), with only 15% located in the main body (Fig. 5A). However, at symmetric synapses, most (89%) GABAB2 immunogold particles were localized in the main body of the synapses (Fig. 5C-E); 41% associated with the presynaptic membrane and 48% with the postsynaptic membrane (Fig. 4B)" |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Niels Cornelisse (ORCID:0000-0001-9425-2935) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 1276 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |