| Annotated protein: | Gamma-aminobutyric acid receptor subunit beta-1 (GABA(A) receptor subunit beta-1). Gene symbol: GABRB1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P15431 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GABRB1 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of presynaptic active zone membrane (GO:0099059) |
| Synapse type(s): | globus pallidus, GABAergic |
| Annotated paper: | Chen L, et al. "Subcellular localization of GABAB receptor subunits in rat globus pallidus" J Comp Neurol. 2004 Jun 28;474(3):340-52 PMID:15174078 |
| Figure(s): | Fig.2B-D, Fig.4, Fig. 6A,B, Fig. 8A,B |
| Annotation description: | GABA B1 subunit detection in Globus pallidus synapses 8/9/2017 Pim - Literal "Most synapse-associated GABAB1 immunogold particles (87%) were observed at perisynaptic sites on the presynaptic (17%) or postsynaptic (70%) membrane (Figs. 2A,B, 4A). In contrast, at symmetric synapses, most (90%) synapse-associated GABAB1 immunogold particles were localized in the main body of the synapse (Fig. 2C-E), accounting for 34% on presynaptic and 56% on postsynaptic membrane (Fig. 4A)." |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Niels Cornelisse (ORCID:0000-0001-9425-2935) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 1274 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |