| Annotated protein: | Gamma-aminobutyric acid receptor subunit alpha-2 (GABA(A) receptor subunit alpha-2). Gene symbol: GABRA2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P23576 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GABRA2 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of presynaptic active zone membrane (GO:0099059) |
| Synapse type(s): | hippocampus, GABAergic |
| Annotated paper: | Nyiri G, et al. "Input-dependent synaptic targeting of alpha(2)-subunit-containing GABA(A) receptors in synapses of hippocampal pyramidal cells of the rat" Eur J Neurosci. 2001 Feb;13(3):428-42 PMID:11168550 |
| Figure(s): | Fig. 2A,C, Fig3A,D |
| Annotation description: | Immuno EM for GABAA alpha 2 in HC pyramidal cells 27/3/2018 Pim - Literal: "Immunoparticles for GABAAreceptor subunitsappeared over the image of the postsynaptic membrane, the synapticcleft and the presynaptic membrane as well as above the pre- andpostsynaptic cytoplasm. This presumably occurs because the centreof immunoparticles may be up to 25 nm from the epitope, and thesynapses are cut at various angles, but the contribution of the presynaptic membrane to the labelling cannot be excluded ...." |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Niels Cornelisse (ORCID:0000-0001-9425-2935) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 1266 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |