Annotated protein:Disintegrin and metalloproteinase domain-containing protein 10 (ADAM 10) (EC 3.4.24.81) (Kuzbanian protein homolog) (Mammalian disintegrin-metalloprotease) (CD antigen CD156c). Gene symbol: ADAM10. Taxonomy: Mus musculus (Mouse). Uniprot ID: O35598
antibody wiki:
SynGO gene info:SynGO data @ ADAM10
Ontology domain:Biological Process
SynGO term:postsynapse organization (GO:0099173)
Synapse type(s):hippocampus, glutamatergic
Annotated paper:Malinverno M, et al. "Synaptic localization and activity of ADAM10 regulate excitatory synapses through N-cadherin cleavage" J Neurosci. 2010 Dec 1;30(48):16343-55 PMID:21123580
Figure(s):Fig.2, 3
Annotation description:Figure 2: "ADAM10 localization and activity influence spine morphology"
Figure 3: "Timing of ADAM10-dependent effect on spine morphology"

8/11/2017 Pim
- Recap: ADAM10 cleaves N-cadherin (a homophilic interactin pre and postsynaptic adhesion molecule). Mislocalization of ADAM10 with a TAT-fused competing peptide or inhibition of ADAM10 activity with TIMP-1 results in spine morphology changes and different synaptic transmission (AMPAR composition, AMPA activity) in vitro and in vivo. I think that the role of N-cadherin in this story is illustrated in a correlational rather than a experimental fashion. No effect on cell adhesion is shown.
Evidence tracking, Biological System:Cultured neurons
Evidence tracking, Protein Targeting:Antagonist / agonist
Evidence tracking, Experiment Assay:Confocal
Annotator(s):Chiara Verpelli (ORCID:0000-0003-2949-9725)
Carlo Sala (ORCID:0000-0003-0662-9523)
Lab:CNR Neuroscience Institute Milan and Dept. of Biotechnology and Translational Medicine, University of Milan, 20129 Milan, Italy
SynGO annotation ID:1253
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology