| Annotated protein: | Gamma-aminobutyric acid type B receptor subunit 1 (GABA-B receptor 1) (GABA-B-R1) (GABA-BR1) (GABABR1) (Gb1). Gene symbol: GABBR1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q9Z0U4 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GABBR1 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of presynaptic membrane (GO:0099056) |
| Synapse type(s): | brainstem |
| Annotated paper: | Barbaresi P, et al. "Cellular and subcellular localization of the GABA(B) receptor 1a/b subunit in the rat periaqueductal gray matter" J Comp Neurol. 2007 Dec 10;505(5):478-92 PMID:17924569 |
| Figure(s): | Fig. 6A,D and table 1 |
| Annotation description: | Immuno EM of GabaBR1 subunit in PAG neuropil. 11/9/2017 Pim - Literal: "On electron microscopy, GABA(B)R(1a/b) IR was mainly on dendrites (54.92% of labeled elements) and axon terminals (21.90%) making synapses with labeled and unlabeled postsynaptic elements" - Literal: "GABABR1a/b IR was mainly on dendritic shafts (Table 1). Often, the reaction product completely filled the dendrites, whereas in other cases it was only on microtubules, on both mitochondrial and cytoplasmic membranes (Fig. 6B-D,F). Staining was mainly observed on nonsynaptic regions of labeled dendrites and frequently also in regions adjacent to the postsynaptic density (Fig. 6B-D)" |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Niels Cornelisse (ORCID:0000-0001-9425-2935) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 1251 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |