| Annotated protein: | Synapsin-2 (Synapsin II). Gene symbol: SYN2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q63537 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SYN2 |
| Ontology domain: | Cellular Component |
| SynGO term: | extrinsic component of synaptic vesicle membrane (GO:0098850) |
| Synapse type(s): | cerebrum |
| Annotated paper: | Boyken J, et al. "Molecular profiling of synaptic vesicle docking sites reveals novel proteins but few differences between glutamatergic and GABAergic synapses" Neuron. 2013 Apr 24;78(2):285-97 PMID:23622064 |
| Figure(s): | Figure 5 |
| Annotation description: | Figure 5: Syn 2 is enriched in the synaptic vesicle fraction 24/10/2017 Pim - Authors note; "Proteins with an iTRAQ ratio of more than 2.5 are considered to be significantly enriched in the docked synaptic vesicle fraction." - Based on the known lipid binding domain of the protein, the "extrinsic component of ... membrane" term was chosen. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | none of the above |
| Evidence tracking, Experiment Assay: | Mass-spectrometry Biochemical fractionation (generic) |
| Annotator(s): | Ruud Toonen (ORCID:0000-0002-9900-4233) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | Synapsin 2 identified in purified SV fraction (Table I) @ PMID:17110340 |
| SynGO annotation ID: | 1232 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |