Annotated protein: | Synapsin-1 (Synapsin I). Gene symbol: SYN1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P09951 |
antibody wiki: | |
SynGO gene info: | SynGO data @ SYN1 |
Ontology domain: | Cellular Component |
SynGO term: | extrinsic component of synaptic vesicle membrane (GO:0098850) |
Synapse type(s): | cerebrum |
Annotated paper: | Boyken J, et al. "Molecular profiling of synaptic vesicle docking sites reveals novel proteins but few differences between glutamatergic and GABAergic synapses" Neuron. 2013 Apr 24;78(2):285-97 PMID:23622064 |
Figure(s): | Figure 5 |
Annotation description: | Figure 5: VPS45 is enriched in the docked synaptic vesicle fraction. 24/10/2017 Pim - Authors note; "Proteins with an iTRAQ ratio of more than 2.5 are considered to be significantly enriched in the docked synaptic vesicle fraction." - Based on the known lipid binding domain of the protein, the "extrinsic component of ... membrane" term was chosen. |
Evidence tracking, Biological System: | Intact tissue |
Evidence tracking, Protein Targeting: | none of the above |
Evidence tracking, Experiment Assay: | Mass-spectrometry Biochemical fractionation (generic) |
Annotator(s): | Ruud Toonen (ORCID:0000-0002-9900-4233) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
Additional literature: | Synapsin 1 identified in purified SV fraction (Table I) @ PMID:17110340 |
SynGO annotation ID: | 1231 |
Dataset release (version): | 20231201 |
View annotation as GO-CAM model: |