| Annotated protein: | Glutamate receptor 4 (GluR-4) (GluR4) (AMPA-selective glutamate receptor 4) (GluR-D) (Glutamate receptor ionotropic, AMPA 4) (GluA4). Gene symbol: GRIA4. Taxonomy: Homo sapiens (Human). Uniprot ID: P48058 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GRIA4 |
| Ontology domain: | Biological Process |
| SynGO term: | ligand-gated ion channel activity involved in regulation of presynaptic membrane potential (GO:0099507) |
| Annotated paper: | Grosskreutz J, et al. "Kinetic properties of human AMPA-type glutamate receptors expressed in HEK293 cells" Eur J Neurosci. 2003 Mar;17(6):1173-8 PMID:12670305 |
| Figure(s): | table 1 |
| Annotation description: | Characterisation of AMPA receptor subunits from outside-out patches from transfected HEK cells. rule: NAS_MFCC-BP rationale: Protein has ligand-gated ion channel receptor activity and is localized in the presynaptic membrane (shown with high-resolution technique). The inference to term ligand-gated ion channel activity involved in regulation of presynaptic membrane potential (GO:0099507) is trivial and non-controversial. Pinf_CC: [P19493] SyNGO ID 1204 (PMID:15610164, EM) |
| Evidence tracking, Biological System: | Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Non-tracable Author Statement (NAS): | This annotation required some inference over additional information/literature, and is not solely based on observations made in the annotated paper by its original authors. |
| Annotator(s): | Niels Cornelisse (ORCID:0000-0001-9425-2935) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 1225 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |