Annotated protein:Glutamate receptor 3 (GluR-3) (AMPA-selective glutamate receptor 3) (GluR-C) (GluR-K3) (Glutamate receptor ionotropic, AMPA 3) (GluA3). Gene symbol: GRIA3. Taxonomy: Homo sapiens (Human). Uniprot ID: P42263
antibody wiki:
SynGO gene info:SynGO data @ GRIA3
Ontology domain:Biological Process
SynGO term:ligand-gated ion channel activity involved in regulation of presynaptic membrane potential (GO:0099507)
Annotated paper:Grosskreutz J, et al. "Kinetic properties of human AMPA-type glutamate receptors expressed in HEK293 cells" Eur J Neurosci. 2003 Mar;17(6):1173-8 PMID:12670305
Figure(s):table 1
Annotation description:Characterisation of AMPA receptor subunits from outside-out patches from transfected HEK cells.

rule: NAS_MFCC-BP
rationale:
Protein has ligand-gated ion channel receptor activity and is localized in the presynaptic membrane (shown with high-resolution technique). The inference to term ligand-gated ion channel activity involved in regulation of presynaptic membrane potential (GO:0099507) is trivial and non-controversial.
Pinf_CC:
[P19492] SyNGO ID 3834 (PMID:12761821, EM)
Evidence tracking, Biological System:Non-neuronal tissue
Evidence tracking, Protein Targeting:Over-expression
Evidence tracking, Experiment Assay:Whole-cell patch clamp
Non-tracable Author Statement (NAS):This annotation required some inference over additional information/literature, and is not solely based on observations made in the annotated paper by its original authors.
Annotator(s):Niels Cornelisse (ORCID:0000-0001-9425-2935)
Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:1224
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology