| Annotated protein: | Synaptosomal-associated protein 47 (SNAP-47) (Synaptosomal-associated 47 kDa protein). Gene symbol: SNAP47. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q6P6S0 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SNAP47 |
| Ontology domain: | Cellular Component |
| SynGO term: | presynaptic active zone (GO:0048786) |
| Synapse type(s): | Mossy fiber synapse (DG->CA3) |
| Annotated paper: | Munster-Wandowski A, et al. "Distinct Localization of SNAP47 Protein in GABAergic and Glutamatergic Neurons in the Mouse and the Rat Hippocampus" Front Neuroanat. 2017 Jul 13;11:56 PMID:28751858 |
| Figure(s): | Fig 8-11 |
| Annotation description: | Figure 10. Quantitative immunoelectron microscopy of SNAP47 immunolabeling in glutamatergic neurons of the rat hippocampus shows labeling on mossy fiber boutons and postsynaptic spines of CA3 pyramidal cells. Labeling for SNAP47 was present in most presynaptic terminals, but at a level lower than that detected in postsynaptic compartments. Fig 11. Ultrastructural localization of SNAP47 in axon terminals and dendrites of GABAergic INs of the mouse hippocampus gives similar result: expression in pre- and postsynaptic neurons 23/10/2017 Pim - In Fig.8/9 the authors show that SNAP47; SNAP-47 is present both pre- and postsynaptically in the Mossy Fiber Projection System of the rat (using ZnT3 and PSD95 as resp. pre and postsynaptic markers). In the mouse, SNAP47; SNAP-47 is predominantly located at the postsynapse (clearly different from the rat species). |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy Confocal |
| Annotator(s): | Ruud Toonen (ORCID:0000-0002-9900-4233) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | Jahn lab using same ab in subcellular fractionations concludes: SNAP-47 has a widespread intracellular distribution that includes synaptic vesicles but also other intracellular membrane pools @ PMID:16621800 |
| SynGO annotation ID: | 1211 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |