Annotated protein:Glycine receptor subunit alpha-1 (Glycine receptor 48 kDa subunit) (Glycine receptor strychnine-binding subunit). Gene symbol: GLRA1. Taxonomy: Homo sapiens (Human). Uniprot ID: P23415
antibody wiki:
SynGO gene info:SynGO data @ GLRA1
Ontology domain:Biological Process
SynGO term:ligand-gated ion channel activity involved in regulation of presynaptic membrane potential (GO:0099507)
Annotated paper:Bormann J, et al. "Residues within transmembrane segment M2 determine chloride conductance of glycine receptor homo- and hetero-oligomers" EMBO J. 1994 Mar 15;13(6):1493 PMID:8137830
Figure(s):Fig. 3A
Annotation description:Expression of Glycine receptor subunits to show functional (ion-channel) properties, here measured by single channel measurements in out-side-out patch configuration.

rule: NAS_MFCC-BP
rationale:
Protein has ligand-gated ion channel receptor activity and is localized in the presynaptic membrane (shown with high-resolution technique). The inference to term ligand-gated ion channel activity involved in regulation of presynaptic membrane potential (GO:0099507) is trivial and non-controversial.
Pinf_CC:
[P07727] SyNGO ID 1129 (PMID:23175852, EM)
Evidence tracking, Biological System:Non-neuronal tissue
Evidence tracking, Protein Targeting:Over-expression
Evidence tracking, Experiment Assay:Whole-cell patch clamp
Non-tracable Author Statement (NAS):This annotation required some inference over additional information/literature, and is not solely based on observations made in the annotated paper by its original authors.
Annotator(s):Niels Cornelisse (ORCID:0000-0001-9425-2935)
Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:1191
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology