| Annotated protein: | Synapsin-2 (Synapsin II). Gene symbol: SYN2. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q64332 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SYN2 |
| Ontology domain: | Biological Process |
| SynGO term: | synaptic vesicle clustering (GO:0097091) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Gitler D, et al. "Synapsin IIa controls the reserve pool of glutamatergic synaptic vesicles" J Neurosci. 2008 Oct 22;28(43):10835-43 PMID:18945891 |
| Figure(s): | Fig. 2, Fig. 3, Fig. 4, Fig. 6 |
| Annotation description: | In this papers, authors used the synapsin I, II and III triple KO mouse and by introducing each synapsin isoform tried to investigate their function. They found that only synapsin II is able to rescue the synaptic depression phenotype of triple KO cultures (Fig.2 and Fig.3). Moreover, using fluorescent microscopy they found that synapsin II increases the density of synaptic vesicles (Fig.4) and the size of the synaptic vesicles reverse pool (Fig.6). Therefore, it can be concluded that synapsin II regulated the clustering of synaptic vesicles. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) Over-expression |
| Evidence tracking, Experiment Assay: | Wide-field fluorescence Electrophysiology (generic) |
| Annotator(s): | Momchil Ninov (ORCID:0000-0002-0808-7003) Mahdokht Kohansalnodehi (ORCID:0000-0002-3898-5197) Reinhard Jahn (ORCID:0000-0003-1542-3498) |
| Lab: | Department of Neurobiology, Max Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany |
| SynGO annotation ID: | 1158 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |