| Annotated protein: | Synaptotagmin-6 (Synaptotagmin VI) (SytVI). Gene symbol: SYT6. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q62746 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SYT6 |
| Ontology domain: | Biological Process |
| SynGO term: | postsynaptic dense core vesicle exocytosis (GO:0150038) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Wong YH, et al. "Activity-dependent BDNF release via endocytic pathways is regulated by synaptotagmin-6 and complexin" Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):E4475-84 PMID:26216953 |
| Figure(s): | Fig 4, 5 and 8 |
| Annotation description: | In this study, Wong et al use quantum dot labelled brain-derived neurotrophic factor (BDNF) in order to study its trafficking in hippocampal neuron cultures (see Fig. 1). The authors show that QD-BDNF is preferentially stored at postsynaptic sites in cultured neurons and that in response to synaptic activity and AMPA and NMDA receptor activation, postsynaptic endosomal BDNF can be exocytosed. Furthermore, postsynaptic endosome exocytosis is suggested to take place at syt 6 positive sites and to be impaired by syt 6 knockdown (Fig 4,5 and Fig 8 for a model). |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | RNAi / shRNA |
| Evidence tracking, Experiment Assay: | Optical physiology |
| Annotator(s): | Momchil Ninov (ORCID:0000-0002-0808-7003) Mahdokht Kohansalnodehi (ORCID:0000-0002-3898-5197) Reinhard Jahn (ORCID:0000-0003-1542-3498) |
| Lab: | Department of Neurobiology, Max Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany |
| SynGO annotation ID: | 1155 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |