| Annotated protein: | Regulating synaptic membrane exocytosis protein 2 (Rab-3-interacting molecule 2) (RIM 2) (Rab-3-interacting protein 2). Gene symbol: RIMS2. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q9EQZ7 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ RIMS2 |
| Ontology domain: | Biological Process |
| SynGO term: | synaptic vesicle docking (GO:0016081) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Kaeser PS, et al. "RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interaction" Cell. 2011 Jan 21;144(2):282-95 PMID:21241895 |
| Figure(s): | Fig2G-H |
| Annotation description: | In cultured RIM1/RIM2 double knockout neurons, there is an about 40% reduction in the number of docked vesicles, as measured by electron microscopy in glutaradehyde fixed cultures. Due to their high homology, the synaptic functions of RIM1 and RIM2 are assumed to be redundant (Han 2015). |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Arthur de Jong (ORCID:0000-0002-7620-2704) Pascal Kaeser (ORCID:0000-0002-1558-1958) |
| Lab: | Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA |
| Additional literature: | Due to their high homology, the synaptic functions of RIM1 and RIM2 are assumed to be redundant (Han 2015). @ PMID:25343783 |
| SynGO annotation ID: | 115 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |