| Annotated protein: | Synaptic vesicular amine transporter (Monoamine transporter) (Solute carrier family 18 member 2) (Vesicular amine transporter 2) (VAT2). Gene symbol: SLC18A2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q01827 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SLC18A2 |
| Ontology domain: | Cellular Component |
| SynGO term: | neuronal dense core vesicle (GO:0098992) |
| Synapse type(s): | striatum, dopaminergic ventral tegmental area, dopaminergic |
| Annotated paper: | Nirenberg MJ, et al. "Ultrastructural localization of the vesicular monoamine transporter-2 in midbrain dopaminergic neurons: potential sites for somatodendritic storage and release of dopamine" J Neurosci. 1996 Jul 1;16(13):4135-45 PMID:8753875 |
| Figure(s): | 6 A and 6 C |
| Annotation description: | Immunogold highlighting distribution in neuronal sub-compartments. Selected figures show synaptic vesicle and dense core vesicle in presynaptic compartment as judged by juxtaposition to the PSD. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Noa Lipstein (ORCID:0000-0002-0755-5899) Cordelia Imig (ORCID:0000-0001-7351-8706) Vincent O'connor (ORCID:0000-0003-3185-5709) Nils Brose (ORCID:0000-0003-0938-8534) |
| Lab: | Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany |
| Additional literature: | Antibody sensitivity and selectivity determined by western blot and pre-absorption with immunizing antigen. @ PMID:7666200 |
| SynGO annotation ID: | 1149 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |