| Annotated protein: | Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1). Gene symbol: MAP2K1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q01986 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ MAP2K1 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic density (GO:0014069) |
| Synapse type(s): | neocortex hippocampus cerebellum |
| Annotated paper: | Suzuki T, et al. "ERK2-type mitogen-activated protein kinase (MAPK) and its substrates in postsynaptic density fractions from the rat brain" Neurosci Res. 1995 Jun;22(3):277-85 PMID:7478291 |
| Figure(s): | Fig 1,3,4 |
| Annotation description: | Authors used MAPKK antisera and detected MAPKK immunoreactivity in PSD fractions prepared from rat cerebral cortex, hippocampus and cerebellum. MAPKK is also present in all analyzed fractions (soluble, synaptosome and synaptic plasma membrane). However, MAPKK immunoreactivity increased following synaptogenesis (3 weeks after birth) in the synaptosomal and PSD fraction which suggests that MAPKK functions in the synapse. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Western blot Biochemical fractionation (generic) |
| Annotator(s): | Maria Andres-Alonso (ORCID:0000-0002-1585-539X) Michael Kreutz (ORCID:0000-0003-0575-6950) |
| Lab: | RG Neuroplasticity, Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany and Leibniz Group 'Dendritic Organelles and Synaptic Function', Center for Molecular Neurobiology, ZMNH, University MC, Hamburg-Eppendorf, Hamburg, 20251, Germany |
| SynGO annotation ID: | 1143 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |