| Annotated protein: | Spectrin beta chain. Gene symbol: SPTBN2. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q68FG2 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SPTBN2 |
| Ontology domain: | Cellular Component |
| SynGO term: | presynapse (GO:0098793) |
| Synapse type(s): | cerebellum |
| Annotated paper: | Zagon IS, et al. "Spectrin subtypes in mammalian brain: an immunoelectron microscopic study" J Neurosci. 1986 Oct;6(10):2977-86 PMID:3531427 |
| Figure(s): | Fig4 |
| Annotation description: | This figures shows the immuno-EM localisation of brain-specific spectrin(240/235) (also called fodrin or calspectrin, that was later renamed to Spectrin beta II). The antibody labels axons (Fig4A,B) and axon terminals (Fig4D,E) specifically with little labelling of dendrites or spines. Preimmune serum does not show positive signal (Fig4F). |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Jan van Weering (ORCID:0000-0001-5259-4945) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 1140 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |