| Annotated protein: | 5-hydroxytryptamine receptor 3A (5-HT3-A) (5-HT3A) (5-hydroxytryptamine receptor 3) (5-HT-3) (5-HT3R) (Serotonin receptor 3A) (Serotonin-gated ion channel receptor). Gene symbol: HTR3A. Taxonomy: Mus musculus (Mouse). Uniprot ID: P23979 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ HTR3A |
| Ontology domain: | Biological Process |
| SynGO term: | ligand-gated ion channel activity involved in regulation of presynaptic membrane potential (GO:0099507) |
| Annotated paper: | Morton RA, et al. "Agonist- and antagonist-induced up-regulation of surface 5-HT3 A receptors" Br J Pharmacol. 2015 Aug;172(16):4066-77 PMID:25989383 |
| Figure(s): | Fig. 1A and 3D |
| Annotation description: | 5-HT3A receptro subunit characterisation in HEK cells. rule: NAS_MFCC-BP rationale: Protein has ligand-gated ion channel receptor activity and is localized in the presynaptic membrane (shown with high-resolution technique). The inference to term ligand-gated ion channel activity involved in regulation of presynaptic membrane potential (GO:0099507) is trivial and non-controversial. Pinf_CC: [P35563] SyNGO ID 1133 (PMID:11876772, EM) |
| Evidence tracking, Biological System: | Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Non-tracable Author Statement (NAS): | This annotation required some inference over additional information/literature, and is not solely based on observations made in the annotated paper by its original authors. |
| Annotator(s): | Niels Cornelisse (ORCID:0000-0001-9425-2935) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 1135 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |