| Annotated protein: | 5-hydroxytryptamine receptor 3A (5-HT3-A) (5-HT3A) (5-hydroxytryptamine receptor 3) (5-HT-3) (5-HT3R) (Serotonin receptor 3A) (Serotonin-gated ion channel receptor). Gene symbol: HTR3A. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P35563 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ HTR3A |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of presynaptic membrane (GO:0099056) |
| Synapse type(s): | dorsal root ganglion (DRG) |
| Annotated paper: | Miquel MC, et al. "Differential subcellular localization of the 5-HT3-As receptor subunit in the rat central nervous system" Eur J Neurosci. 2002 Feb;15(3):449-57 PMID:11876772 |
| Figure(s): | fig.3B-D |
| Annotation description: | Immuno EM of 5-HT3A receptor 8/9/2017 Pim - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen. - literal: "The immunolabelling is found principally associated with axons and nerve terminals. Axonal profiles are filled with immunoperoxidase staining, while discrete spots of immunoreactivity are found on and near the plasma membrane of nerve terminals but not on synaptic profiles (arrow, D)" |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Niels Cornelisse (ORCID:0000-0001-9425-2935) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 1133 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |