| Annotated protein: | Glutamate receptor ionotropic, kainate 5 (GluK5) (Excitatory amino acid receptor 2) (EAA2) (Glutamate receptor KA-2) (KA2). Gene symbol: GRIK5. Taxonomy: Homo sapiens (Human). Uniprot ID: Q16478 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GRIK5 |
| Ontology domain: | Biological Process |
| SynGO term: | ligand-gated ion channel activity involved in regulation of presynaptic membrane potential (GO:0099507) |
| Annotated paper: | Barberis A, et al. "GluR6/KA2 kainate receptors mediate slow-deactivating currents" J Neurosci. 2008 Jun 18;28(25):6402-6 PMID:18562611 |
| Figure(s): | Fig.1B,D-I, Fig. 2 |
| Annotation description: | GluK5 (GRIK5) receptor. rule: NAS_MFCC-BP rationale: Protein has ligand-gated ion channel receptor activity and is localized in the presynaptic membrane (shown with high-resolution technique). The inference to term ligand-gated ion channel activity involved in regulation of presynaptic membrane potential (GO:0099507) is trivial and non-controversial. Pinf_CC: [Q61626] SyNGO ID 1116 (PMID:16360275, EM) [H9EM65] SyNGO ID 1121 (PMID:12954862, EM) |
| Evidence tracking, Biological System: | Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Non-tracable Author Statement (NAS): | This annotation required some inference over additional information/literature, and is not solely based on observations made in the annotated paper by its original authors. |
| Annotator(s): | Niels Cornelisse (ORCID:0000-0001-9425-2935) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 1132 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |