| Annotated protein: | Regulating synaptic membrane exocytosis protein 2 (Rab-3-interacting molecule 2) (RIM 2) (Rab-3-interacting protein 2). Gene symbol: RIMS2. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q9EQZ7 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ RIMS2 |
| Ontology domain: | Biological Process |
| SynGO term: | synaptic vesicle priming (GO:0016082) |
| Synapse type(s): | hippocampus, GABAergic |
| Annotated paper: | Kaeser PS, et al. "RIM genes differentially contribute to organizing presynaptic release sites" Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11830-5 PMID:22753485 |
| Figure(s): | supplemental figure 4 |
| Annotation description: | RIM2 knockout cultures have a reduction in the size of the sucrose pool at inhibitory synapses, demonstrating a role for RIM2 in vesicle priming. Due to the strong homology between RIM1 and RIM2, both proteins are assumed to be redundant in this process. Action potential mediated pool measurements have confirmed a role in priming for RIM1 and RIM2 at the Calyx of Held (Han et.al. 2011). |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Annotator(s): | Arthur de Jong (ORCID:0000-0002-7620-2704) Pascal Kaeser (ORCID:0000-0002-1558-1958) |
| Lab: | Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA |
| Additional literature: | Due to the strong homology between RIM1 and RIM2, both proteins are assumed to be redundant in this process (Han 2015). @ PMID:25343783 Action potential mediated pool measurements have confirmed a role in priming at the Calyx of Held (Han et.al. 2011). @ PMID:21262468 |
| SynGO annotation ID: | 113 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |