| Annotated protein: | Alpha-1A adrenergic receptor (Alpha-1A adrenoreceptor) (Alpha-1A adrenoceptor) (Alpha-1C adrenergic receptor). Gene symbol: ADRA1A. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P43140 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ADRA1A |
| Ontology domain: | Biological Process |
| SynGO term: | presynaptic modulation of chemical synaptic transmission (GO:0099171) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Croce A, et al. "Opposite effects of alpha 1- and beta-adrenoceptor stimulation on both glutamate- and gamma-aminobutyric acid-mediated spontaneous transmission in cultured rat hippocampal neurons" J Neurosci Res. 2003 Feb 15;71(4):516-25 PMID:12548707 |
| Figure(s): | Fig.4 |
| Annotation description: | Application of noradrenaline to cultured hippocampal neurons induces a reduction in the frequency of miniature EPSCs (Fig 4). Application of the selective alpha1-agonist cirazoline also induced a reduction in the mEPSC frequency, but no change in mEPSC amplitude (Fig. 4d, f). These findings indicate that presynaptic G-Protein coupled Alpha1-adrenergic receptors modulate synaptic transmission upon activation. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Annotator(s): | Noa Lipstein (ORCID:0000-0002-0755-5899) Cordelia Imig (ORCID:0000-0001-7351-8706) Vincent O'connor (ORCID:0000-0003-3185-5709) Nils Brose (ORCID:0000-0003-0938-8534) |
| Lab: | Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany |
| SynGO annotation ID: | 1101 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |