| Annotated protein: | Alpha-2C adrenergic receptor (Alpha-2 adrenergic receptor subtype C4) (Alpha-2C adrenoreceptor) (Alpha-2C adrenoceptor) (Alpha-2CAR). Gene symbol: ADRA2C. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P22086 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ADRA2C |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic density membrane (GO:0099061) |
| Synapse type(s): | pons, glutamatergic |
| Annotated paper: | Lee A, et al. "Ultrastructural evidence for prominent postsynaptic localization of alpha2C-adrenergic receptors in catecholaminergic dendrites in the rat nucleus locus coeruleus" J Comp Neurol. 1998 May 4;394(2):218-29 PMID:9552127 |
| Figure(s): | Fig. 1-5 |
| Annotation description: | Pre-embedding immuno-peroxidase labelling for electron microscopy indicates the presence of Alpha2C Adrenergic receptor (Alpha2C-AR) immunoreactivity in dendrites in the nucleus locus coeruleus. Alpha2C-AR immunoreactivity was often associated with plasma membrane regions apposed to astrocytes or presynaptic terminals, and frequently adjacent to postsynaptic densities (Fig. 2B, 3B). However, immunoreactivity was also found at a distance from the PSD at the membrane as well as in the cytoplasm of dendrites and endomembranes. Preabsorption of the antibody with the peptide completely abolishes immunostaining (Fig. 1B). |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Noa Lipstein (ORCID:0000-0002-0755-5899) Cordelia Imig (ORCID:0000-0001-7351-8706) Vincent O'connor (ORCID:0000-0003-3185-5709) Nils Brose (ORCID:0000-0003-0938-8534) |
| Lab: | Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany |
| SynGO annotation ID: | 1085 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |