| Annotated protein: | Alpha-2A adrenergic receptor (Alpha-2A adrenoreceptor) (Alpha-2A adrenoceptor) (Alpha-2AAR) (Alpha-2D adrenergic receptor) (CA2-47). Gene symbol: ADRA2A. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P22909 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ADRA2A |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic membrane (GO:0099055) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Milner TA, et al. "Hippocampal alpha2a-adrenergic receptors are located predominantly presynaptically but are also found postsynaptically and in selective astrocytes" J Comp Neurol. 1998 Jun 8;395(3):310-27 PMID:9596526 |
| Figure(s): | Table 1, Fig. 1, 3, 4, 6, 8, 9 |
| Annotation description: | Pre-embedding immuno-peroxidase labelling for electron microscopy indicates the presence of Alpha2A Adrenergic receptor (Alpha2A-AR) immunoreactivity in some dendrites and spines in the hippocampus (Fig. 3, 4, 6, 8, 9). Immunoreactive postsynapses were "exclusively asymmetric contacts". Alpha2A-AR immunoreactivity was often intense at the postsynaptic density and perisynaptic region (figure legend Fig. 3). Preabsorption of the antibody with the peptide completely abolishes immunostaining (Fig. 1C). |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antagonist / agonist Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Noa Lipstein (ORCID:0000-0002-0755-5899) Cordelia Imig (ORCID:0000-0001-7351-8706) Vincent O'connor (ORCID:0000-0003-3185-5709) Nils Brose (ORCID:0000-0003-0938-8534) |
| Lab: | Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany |
| SynGO annotation ID: | 1082 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |