Annotated protein:Alpha-2A adrenergic receptor (Alpha-2A adrenoreceptor) (Alpha-2A adrenoceptor) (Alpha-2AAR) (Alpha-2D adrenergic receptor) (CA2-47). Gene symbol: ADRA2A. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P22909
antibody wiki:
SynGO gene info:SynGO data @ ADRA2A
Ontology domain:Cellular Component
SynGO term:integral component of postsynaptic density membrane (GO:0099061)
Synapse type(s):hippocampus, glutamatergic
Annotated paper:Milner TA, et al. "Hippocampal alpha2a-adrenergic receptors are located predominantly presynaptically but are also found postsynaptically and in selective astrocytes" J Comp Neurol. 1998 Jun 8;395(3):310-27 PMID:9596526
Figure(s):Table 1, Fig. 1, 3, 4, 6, 8, 9
Annotation description:Pre-embedding immuno-peroxidase labelling for electron microscopy indicates the presence of Alpha2A Adrenergic receptor (Alpha2A-AR) immunoreactivity in some dendrites and spines in the hippocampus (Fig. 3, 4, 6, 8, 9). Immunoreactive postsynapses were "exclusively asymmetric contacts". Alpha2A-AR immunoreactivity was often intense at the postsynaptic density and perisynaptic region (figure legend Fig. 3).

Preabsorption of the antibody with the peptide completely abolishes immunostaining (Fig. 1C).
Evidence tracking, Biological System:Intact tissue
Evidence tracking, Protein Targeting:Antibody (detection)
Evidence tracking, Experiment Assay:Electron Microscopy
Annotator(s):Noa Lipstein (ORCID:0000-0002-0755-5899)
Cordelia Imig (ORCID:0000-0001-7351-8706)
Vincent O'connor (ORCID:0000-0003-3185-5709)
Nils Brose (ORCID:0000-0003-0938-8534)
Lab:Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany
SynGO annotation ID:1081
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology