| Annotated protein: | Ephrin-B3. Gene symbol: EFNB3. Taxonomy: Mus musculus (Mouse). Uniprot ID: O35393 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ EFNB3 |
| Ontology domain: | Biological Process |
| SynGO term: | trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission (GO:0099557) |
| Synapse type(s): | hippocampus, glutamatergic Mossy fiber synapse (DG->CA3) |
| Annotated paper: | Armstrong JN, et al. "B-ephrin reverse signaling is required for NMDA-independent long-term potentiation of mossy fibers in the hippocampus" J Neurosci. 2006 Mar 29;26(13):3474-81 PMID:16571754 |
| Figure(s): | Fig 3, 4, 5 |
| Annotation description: | Mossy fiber posttetanic potentiation (PTP) and LTP measured in CA3 granule neurons after tetanic stimulation induced in the stratum lucidum is impaired in hetero- and homozygotic ephrin-B3lacZ mice that express a mutant, likely dominant-negative (Fig. 4), version of ephrin-B3 (β-galactosidase fused to intracellular C-terminus of ephrin-B3) (Fig 3). Short-term plasticity in the mossy fibers in these mice was normal (Fig. 5) |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp Electrophysiology (generic) |
| Annotator(s): | Tony Cijsouw (ORCID:0000-0003-0912-1514) Thomas Biederer (ORCID:0000-0002-3670-7863) |
| Lab: | Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA |
| Additional literature: | Disrupting interactions between postsynaptic PDZ scaffolding proteins and Eph receptors in CA3 pyramidal neurons disrupted mossy fiber LTP In addition, application of fc fusion proteins that disrupt EphB to B-ephrin signaling were also able to block stable mossy fiber LTP. Together, this indicates that a trans-synaptic signal is required for mossy fibers to undergo LTP @ PMID:12052960 |
| SynGO annotation ID: | 1046 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |