| Annotated protein: | Presenilin (EC 3.4.23.-). Gene symbol: PSEN1. Taxonomy: Macaca Mulatta (Rhesus Macaque). Uniprot ID: F7AGU8 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PSEN1 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic SER |
| Synapse type(s): | brain, glutamatergic |
| Annotated paper: | Lah JJ, et al. "Light and electron microscopic localization of presenilin-1 in primate brain" J Neurosci. 1997 Mar 15;17(6):1971-80 PMID:9045726 |
| Figure(s): | Figure 8 |
| Annotation description: | Using an antibody raised against human presenilin-1 authors show the accumulation of presenilin immunoreactivity in the dendrite in membrane below the PSD. They comment on a more modest pre-synaptic staining. 22/8/2017 Pim - Authors state: "The immunoreactivity localized to tubulovesicular profiles (asterisks), which likely represent elements of the SER (PSD, postsynaptic density)" |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Noa Lipstein (ORCID:0000-0002-0755-5899) Cordelia Imig (ORCID:0000-0001-7351-8706) Vincent O'connor (ORCID:0000-0003-3185-5709) Nils Brose (ORCID:0000-0003-0938-8534) |
| Lab: | Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany |
| SynGO annotation ID: | 1035 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |