| Annotated protein: | Protein wntless homolog (Integral membrane protein GPR177) (Protein evenness interrupted homolog) (EVI). Gene symbol: WLS. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q6P689 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ WLS |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | pons, noradrenaline |
| Annotated paper: | Jaremko KM, et al. "Morphine-induced trafficking of a mu-opioid receptor interacting protein in rat locus coeruleus neurons" Prog Neuropsychopharmacol Biol Psychiatry. 2014 Apr 3;50:53-65 PMID:24333843 |
| Figure(s): | Figure 3 |
| Annotation description: | The paper uses immunogold-silver detection to study the subcellular localization of WLS in noradrenergic locus coeruleus neurons. Wls is a multi-pass transmembrane glycoprotein essential for Wnt cell signaling. Figure 3 shows silver deposits in somatodendritic processes apposing a presynaptic, vesicle-filled terminal. Some deposits are associated with the plasma membrane. Since that a clear association with sub cellular organelles is not seen or mentioned, and the membrane association is not directly at the postsynaptic membrane, one can (only) use the above-mentioned data to demonstrate a post-synaptic localization of Wls. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Noa Lipstein (ORCID:0000-0002-0755-5899) Cordelia Imig (ORCID:0000-0001-7351-8706) Vincent O'connor (ORCID:0000-0003-3185-5709) Nils Brose (ORCID:0000-0003-0938-8534) |
| Lab: | Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany |
| SynGO annotation ID: | 1023 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |