| Annotated protein: | Cell adhesion molecule 1 (Immunoglobulin superfamily member 4) (IgSF4) (Nectin-like protein 2) (NECL-2) (Spermatogenic immunoglobulin superfamily) (SgIgSF) (Synaptic cell adhesion molecule) (SynCAM) (Tumor suppressor in lung cancer 1) (TSLC-1). Gene symbol: CADM1. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8R5M8 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CADM1 |
| Ontology domain: | Biological Process |
| SynGO term: | retrograde trans-synaptic signaling by trans-synaptic protein complex (GO:0098942) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Cheadle L, et al. "The novel synaptogenic protein Farp1 links postsynaptic cytoskeletal dynamics and transsynaptic organization" J Cell Biol. 2012 Dec 10;199(6):985-1001 PMID:23209303 |
| Figure(s): | Fig. 6 |
| Annotation description: | The results in Fig. 6C,D show that SynCAM 1 is required so that the postsynaptic protein Farp1 can regulate presynaptic active zone composition. Specifically, elevating Farp1 selectively in postsynaptic neurons increases the intensity of staining for the active zone marker Bassoon in presynaptic neurons that form inputs onto these neurons, and this Farp1-dependent increase in Bassoon intensity does not occur when SynCAM 1 is knocked-out. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Tony Cijsouw (ORCID:0000-0003-0912-1514) Thomas Biederer (ORCID:0000-0002-3670-7863) |
| Lab: | Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA |
| SynGO annotation ID: | 1019 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |