| Annotated protein: | Adenosine receptor A2a. Gene symbol: ADORA2A. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P30543 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ADORA2A |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic membrane (GO:0099055) |
| Synapse type(s): | medulla |
| Annotated paper: | Pickel VM, et al. "Subcellular distributions of adenosine A1 and A2A receptors in the rat dorsomedial nucleus of the solitary tract at the level of the area postrema" Synapse. 2006 Dec 1;60(7):496-509 PMID:16952160 |
| Figure(s): | Fig. 2-6, Table 1 and 2. |
| Annotation description: | The location of the adenosine A2A receptor was assessed by pre-embedding immunoperoxidase and immunogold labelling. The A2A receptor was found in dendrites and spines (Table1 and 2, Fig.2-6). Immunoreactivity was found on plasma membranes and endomembranes. A monoclonal, mouse, antiserum was raised against the human adenosine A2A receptor (clone 7F6-G5-A2, Upstate USA, Charlotteswville, VA). The antibody produced the same immunoreactivity pattern in wildtype mice, but not in A2A KO mice (data not shown in this paper). |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Noa Lipstein (ORCID:0000-0002-0755-5899) Cordelia Imig (ORCID:0000-0001-7351-8706) Vincent O'connor (ORCID:0000-0003-3185-5709) Nils Brose (ORCID:0000-0003-0938-8534) |
| Lab: | Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany |
| SynGO annotation ID: | 1010 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |