| Annotated protein: | SPARC-like protein 1 (Extracellular matrix protein 2) (Matrix glycoprotein Sc1). Gene symbol: SPARCL1. Taxonomy: Mus musculus (Mouse). Uniprot ID: P70663 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SPARCL1 |
| Ontology domain: | Biological Process |
| SynGO term: | synapse adhesion between pre- and post-synapse (GO:0099560) |
| Synapse type(s): | thalamus, glutamatergic |
| Annotated paper: | Singh SK, et al. "Astrocytes Assemble Thalamocortical Synapses by Bridging NRX1alpha and NL1 via Hevin" Cell. 2016 Jan 14;164(1-2):183-196 PMID:26771491 |
| Figure(s): | Fig. 4, 5 |
| Annotation description: | Using heterologous expression systems (HEK293 or COS cells) in combination with primary cultures of retina ganglia cells, the authors show that hevin bridges NRX1alpha and NL1B (Fig. 4). Fig. 5 shows using respective mouse mutants that hevin indeed is required for thalamocortical synapse formation. |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) Over-expression Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal Protein-protein interaction (generic) |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| SynGO annotation ID: | 1004 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |